Synthesis and insecticidal activity of some nicotinic acid derivatives

Nicotinic acid containing pyridine nucleus having side chain at third position gives the significant effect on toxicity to the insects. Therefore, we have reported the synthesis of some nicotinic acid derivatives and their insecticidal activities. The strategy employed for the synthesis of desired nicotinic acid derivatives involved esterification of nicotinic acid. The methyl nicotinate get derivatise by 2-Fluorophenyl urea, 3-trifluoro methylphenyl urea, DL-norleucine, 2, 4-dichlorophenoxy acetic acid hydrazone and diethyl malonate which are further reacted with thiourea to get corresponding condensed product (1a-e). Further methyl nicotinate react with hydrazine hydrate to form nicotinoyl hydrazine (2). This when condensed with substituted aryl aldehydes gave the corresponding arylidene derivatives (3a -e). The structures of these synthesized compounds are confirmed on the basis of IR, PMR and Mass spectral analysis. Most of them showed the promising activity against Green peach aphid, Myzus persicae (Sulzer), American bollworm, Helicoverpa armigera (Hubner) and stored grain pest, Maize weevil, Sitophiles zeamais (Motschulsky).